The parameter column volume (CV) is especially useful to determine scale-up factors. Some chemists think the internal volume of the cartridge (or column) without packing material inside is the column volume. However, the volume of an empty column is not the CV. The CV of any column or cartridge is the volume of the space not occupied by the material pre-packed in a column. This volume includes both the interstitial volume (the volume of the space outside the packed particles) and the particle’s own internal porosity (pore volume).
Post time: Jul-13-2022